AgelessRx vs SystemLabs
Side-by-side comparison of pricing, physician credentials, pharmacy standards, and lab monitoring protocols.
| Criteria | AgelessRx | SystemLabs |
|---|---|---|
| Starting Price | $99/mo | $179/mo |
| Our Score | 8.9 Very Good | 9.7 Outstanding |
| Best For | Longevity-focused telehealth with sermorelin as an injection or intranasal spray | Lab-driven sermorelin and peptide protocols for performance and longevity |
| Badge | Nasal Spray Option | Advanced Protocols |
| No Insurance Needed | ✓ | Lab-Driven |
| Fully Online | ✓ | Peptide Stack |
| Nasal Spray Available | ✓ | No Insurance Needed |
AgelessRx
Longevity-focused telehealth with sermorelin as an injection or intranasal spray
Pros
- Lowest published entry price of any provider offering a nasal delivery form
- Intranasal option at 1000 mcg/mL for patients who will not self-inject
- No membership or consultation fee layered on top of medication cost
- 503A compounding pharmacies disclosed publicly, with all 50 states served
Cons
- Baseline IGF-1 testing is not required before prescribing and labs are not included
- Asynchronous intake only, with no live video consultation option
- Cold-shipped injectables are not reliably deliverable to Alaska or Hawaii
SystemLabs
Lab-driven sermorelin and peptide protocols for performance and longevity
Pros
- Requires baseline IGF-1 before prescribing — clinically correct approach
- Advanced peptide stacking options available
- Performance and recovery-focused protocol design
- Transparent lab-based dosing adjustments
Cons
- More intensive onboarding than simpler platforms
- Not ideal for patients seeking a fast start without labs
Overview
AgelessRx[1] is a budget asynchronous program: $99 per month injectable, no membership fee, no baseline labs required[1]. SystemLabs[2] is the opposite model at $219 per month with a $109 first-month rate[2], built on baseline IGF-1 testing and peptide stacking with BPC-157, ipamorelin, or CJC-1295. This is the widest clinical gap in the AgelessRx set.
At a Glance
| Metric | AgelessRx | SystemLabs |
|---|---|---|
| Starting price | $99/mo injection, $199/mo nasal | $109 first mo, then $219/mo |
| Baseline IGF-1 | Not required, labs not included | Required before prescribing |
| Protocol type | Monotherapy only | Stacking with BPC-157, ipamorelin, CJC-1295 |
| Delivery form | Injectable + intranasal spray | Injectable + ODT |
| 6-month cost | $594 medication only | $1,204 with lab-driven titration |
Key Differences
Baseline IGF-1 is the whole argument
Sermorelin is a GHRH analog. It stimulates the pituitary and does not deliver GH directly, and its output is limited by somatostatin feedback. That mechanism only makes sense to dose against a known baseline IGF-1, because the IGF-1 response to GHRH-analog therapy is what holds through 12 weeks[4] and there is nothing else to measure. SystemLabs requires baseline IGF-1 before it will prescribe and adjusts dosing on lab results. AgelessRx states plainly that no bloodwork is required[3] and does not include labs in the price. Prescribing without a baseline is the weaker standard and it is the single largest mark against AgelessRx here.
Monotherapy versus stacked protocols
AgelessRx prescribes sermorelin as monotherapy in injection or nasal form. Its breadth is elsewhere in the longevity catalog: metformin, low-dose naltrexone, rapamycin, NAD+. SystemLabs stacks sermorelin with BPC-157, ipamorelin, or CJC-1295 on indication[2] and offers a Sermorelin ODT alongside the injectable[5]. Ipamorelin is the preferred GHRP for stacking because it does not raise cortisol or prolactin. A patient who wants a stacked GH-axis protocol has one option between these two.
Cost per protocol, honestly stated
Six months at AgelessRx costs $594 for the injection and no labs. Six months at SystemLabs costs $1,204 at $109 for the first month then $219[2], with baseline testing and lab-driven titration included. That is roughly double. SystemLabs also carries its own cost of entry: intake takes longer and a patient who wants to start this week will not. AgelessRx ships faster and cheaper, and the asynchronous physician review with no video visit[3] is exactly why.
In Depth
The lab gap in practical terms
SystemLabs requires baseline IGF-1 before it will prescribe and adjusts dosing against lab results. AgelessRx requires no bloodwork at all[3]. Sermorelin is a GHRH analog acting on the pituitary under somatostatin feedback, so IGF-1 is the only readout that tells a prescribing physician whether the protocol is working. The IGF-1 response to GHRH-analog therapy holds through 12 weeks[4], which is why baseline plus a 90-day retest is the standard checkpoint. Skipping the baseline means the 90-day number has nothing to be compared against.
Monotherapy against stacked protocols
SystemLabs stacks sermorelin with BPC-157, ipamorelin, or CJC-1295 on indication[2]. Ipamorelin is the preferred GHRP in a stack because it does not raise cortisol or prolactin, and CJC-1295 carries a 6 to 8 day half-life for less frequent dosing. AgelessRx prescribes sermorelin as monotherapy. Its breadth is elsewhere: metformin, low-dose naltrexone, rapamycin, and NAD+ sit in the same catalog, which is a healthspan build rather than a GH-axis one.
Cost across a full protocol
SystemLabs runs $109 for the first month then $219[2], so 6 months costs $1,204 with baseline testing and lab-driven titration inside that figure. AgelessRx runs $99 per month[1] for $594 over the same period, medication only. The difference of $610 partly buys labs a patient would otherwise pay for. Compare the delta against retail IGF-1 panel pricing before treating AgelessRx as the cheaper program.
Speed to start and delivery forms
AgelessRx uses asynchronous physician review with no video visit[3], which is why it starts faster and costs less. It offers the intranasal spray at 1000 mcg/mL[1]. SystemLabs offers a Sermorelin ODT alongside the injectable with free 2-day shipping and 3rd-party lab tested compounds from a certified U.S. pharmacy[5]. Both cover the needle-averse patient. Only AgelessRx does it through the nasal route.
Choose AgelessRx if
AgelessRx fits a cost-constrained patient who already has recent IGF-1 numbers from their own physician, or who wants the intranasal form[1] that SystemLabs does not offer. It is not the right platform for someone starting sermorelin with no lab history.
Visit AgelessRx →Choose SystemLabs if
SystemLabs is the clinically correct choice for a first protocol. Baseline IGF-1 before prescribing, 3rd-party lab tested compounds from a certified U.S. pharmacy, and stacking with ipamorelin or CJC-1295 on indication[2] is the model a prescribing physician should want. It costs roughly double and the onboarding is slower.
Visit SystemLabs →Bottom line
These are not the same product at different prices. SystemLabs runs a lab-driven protocol with stacking options. AgelessRx sells cheap monotherapy with no baseline requirement. Pay the difference for SystemLabs unless you are bringing your own labs or you need the nasal delivery form.
Frequently Asked Questions
Why does SystemLabs require labs when AgelessRx does not?
SystemLabs prescribes against baseline IGF-1 and titrates on the result, which is the correct standard for a GHRH analog. AgelessRx states no bloodwork is required[3] and reviews intake asynchronously instead. The AgelessRx model is faster and cheaper. It also means the prescribing physician is dosing without knowing where the patient started on the GH axis.
Can I add ipamorelin or CJC-1295 at AgelessRx?
No. AgelessRx prescribes sermorelin as monotherapy in injection or nasal form. SystemLabs offers stacking with BPC-157, ipamorelin, or CJC-1295 on indication[2]. Patients who want a stacked GH-axis protocol have one option between these two.
Is AgelessRx worth it if I already have recent IGF-1 results?
That is the scenario where AgelessRx makes clinical sense. If a patient brings baseline IGF-1 from their own physician and plans a 90-day retest independently, the main weakness in the AgelessRx model is already covered, and the $99 per month price[1] saves roughly $610 over 6 months against SystemLabs.
How long before either protocol shows results?
Sleep quality is typically the first reported change, within 2 to 4 weeks of consistent bedtime subcutaneous dosing. Peak IGF-1 response lands around 90 days, and a full 6 months is the minimum before judging body composition outcomes. That timeline is identical at both providers. Only SystemLabs measures against it with included labs.
References
- Sermorelin: product page (injection from $99/month, no membership or consultation fee, free shipping, 503A compounding pharmacies, asynchronous physician review, patients 30 and over, all 50 states) agelessrx.com, 2026. https://agelessrx.com/agelessrx_product/sermorelin/
- Sermorelin: product page (pricing, online intake, certified U.S. pharmacy, 3rd-party lab testing, free 2-day shipping, ongoing clinician support) systemlabs.com, 2026. https://www.systemlabs.com/treatments/sermorelin
- FAQ (asynchronous physician review with no video visit, no bloodwork required, cancel anytime with 48-hour notice, no minimum term, screening exclusions and shipping terms) agelessrx.com, 2026. https://agelessrx.com/faq/
- Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women J Clin Endocrinol Metab, 1997. PMID 9141536. https://pubmed.ncbi.nlm.nih.gov/9141536/
- Treatments: product catalog (Sermorelin injection and Sermorelin ODT) systemlabs.com, 2026. https://www.systemlabs.com/treatments